Search

  • Fale Conosco
  • Pedido rápido

OriGene

LDLR Monoclonal Antibody (OTI7C5), TrueMAB™

View all (44) LDLR antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
LDLR Monoclonal Antibody (OTI7C5), TrueMAB™

Product Details

TA812510

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Flow Cytometry (Flow)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI7C5

Immunogen

Full length human recombinant protein of human LDLR produced in HEK293T cell.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3; unnamed protein product

View more View less

Gene Aliases: FH; FHC; FHCL1; LDLCQ2; LDLR

View more View less

UniProt ID: (Human) P01130

View more View less

Entrez Gene ID: (Human) 3949

View more View less

Function(s)
beta-amyloid binding virus receptor activity protease binding low-density lipoprotein receptor activity calcium ion binding protein binding low-density lipoprotein particle binding very-low-density lipoprotein particle receptor activity clathrin heavy chain binding identical protein binding binding, bridging lipoprotein particle binding
Process(es)
retinoid metabolic process negative regulation of receptor recycling lipid metabolic process lipid transport endocytosis receptor-mediated endocytosis phagocytosis long-term memory steroid metabolic process cholesterol metabolic process negative regulation of macromolecule metabolic process positive regulation of gene expression negative regulation of gene expression positive regulation of triglyceride biosynthetic process regulation of phosphatidylcholine catabolic process negative regulation of low-density lipoprotein particle clearance phospholipid transport intestinal cholesterol absorption cholesterol transport plasma lipoprotein particle clearance low-density lipoprotein particle clearance high-density lipoprotein particle clearance lipoprotein metabolic process lipoprotein catabolic process cholesterol homeostasis viral entry into host cell artery morphogenesis positive regulation of inflammatory response negative regulation of multicellular organismal process regulation of protein metabolic process negative regulation of protein metabolic process establishment of localization in cell artery development response to caloric restriction negative regulation of astrocyte activation cholesterol import cellular response to fatty acid cellular response to low-density lipoprotein particle stimulus receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport regulation of cholesterol metabolic process beta-amyloid clearance amyloid-beta clearance by cellular catabolic process negative regulation of microglial cell activation positive regulation of lysosomal protein catabolic process negative regulation of amyloid fibril formation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support