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NeoBiotechnologies
Granulocyte-Colony Stimulating Factor (G-CSF) Monoclonal Antibody (CSF3/4597)
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Product Details
1440-MSM7-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CSF3/4597
Immunogen
Recombinant fragment (around aa1-200) of human CSF3 protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Human tonsil or lymph node.
Cellular Location: Cytoplasm.
Target Information
G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet's syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSF 3; CSF3; filgrastim; G-CSF; granulocyte colony stimulating factor precursor; Granulocyte colony-stimulating factor; granulocyte-colony stimulating factor; granulocyte-colony stimulating factor precursor; gsf3; lenograstim; MGC45931; Pluripoietin; RP23-395E10.4; unnamed protein product
Gene Aliases: C17orf33; CSF3; CSF3OS; GCSF
UniProt ID: (Human) P09919
Entrez Gene ID: (Human) 1440
immune response
positive regulation of cell proliferation
cytokine-mediated signaling pathway
positive regulation of actin filament polymerization
granulocyte differentiation
granulocyte colony-stimulating factor signaling pathway
response to ethanol
positive regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
regulation of actin filament organization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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