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Invitrogen
CaMKII beta Monoclonal Antibody (CB-beta-1)
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FIGURE: 1 / 23
CaMKII beta Antibody (13-9800) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), U-87MG (Lane 2) and PC12 (Lane 3). The blots were probed with Anti-CaM Kinase II beta Mouse Monoclonal Antibody (Product # 13-9800, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Secondary Antibody, HRP conjugate (Product # 62-6520, 1:4000 dilution). A 70 kDa band corresponding to CaM Kinase II beta was observed only in PC12. As it is a Rat immunogen, it did not react with human cell lines. Known quantity of pr... View More
Product Details
13-9800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Human,
Mouse,
Sheep,
Rat,
Sea urchin
Published species
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
CB-beta-1
Immunogen
Purified rat brain CaM Kinase.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; Ca++/calmodulin-dependent protein kinase II beta subunit; Calcium, calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; CaMK II; caMK-II subunit beta; MGC29528; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product; β CaMKII; βCaMKII
Gene Aliases: CAM2; CAMK2; CAMK2B; Camk2d; CAMKB; CaMKIIbeta; Ck2b; MRD54
UniProt ID: (Human) Q13554, (Rat) P08413, (Mouse) P28652
Entrez Gene ID: (Human) 816, (Sheep) 101118870, (Rat) 24245, (Mouse) 12323
nucleotide binding
actin binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
identical protein binding
protein homodimerization activity
protein serine kinase activity
phospholipase binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
signal transduction
nervous system development
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
cell differentiation
protein autophosphorylation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
regulation of synapse structural plasticity
regulation of calcium ion transport
long-term synaptic potentiation
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of protein localization to plasma membrane
regulation of neuron migration
G1/S transition of mitotic cell cycle
inhibitory G-protein coupled receptor phosphorylation
calcium ion transport
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
cell projection morphogenesis
neuromuscular process controlling balance
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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