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Proteintech
Alpha galactosidase A Polyclonal Antibody
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FIGURE: 1 / 29
Alpha galactosidase A Antibody (15428-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 15428-1-AP) (Alpha galactosidase A antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
15428-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Alpha galactosidase A Fusion Protein Ag7609 (81-425 aa encoded by BC002689)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WKDAGYEYL CIDDCWMAPQ RDSEGRLQAD PQRFPHGIRQ LANYVHSKGL KLGIYADVGN KTCAGFPGSF GYYDIDAQTF ADWGVDLLKF DGCYCDSLEN LADGYKHMSL ALNRTGRSIV YSCEWPLYMW PFQKPNYTEI RQYCNHWRNF ADIDDSWKSI KSILDWTSFN QERIVDVAGP GGWNDPDMLV IGNFGLSWNQ QVTQMALWAI MAAPLFMSND LRHISPQAKA LLQDKDVIAI NQDPLGKQGY QLRQGDNFEV WERPLSGLAW AVAMINRQEI GGPRSYTIAV ASLGKGVACN PACFITQLLP VKRKLGFYEW TSRLRSHINP TGTVLLQLEN TMQMSL (81-425 aa encoded by BC002689)
Target Information
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: agalsidase alfa; Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; alpha-D-galactoside galactohydrolase 1; alpha-gal A; Alpha-galactosidase A; Galactosylgalactosylglucosylceramidase GLA; Melibiase; unnamed protein product
Gene Aliases: Ags; GALA; GLA
UniProt ID: (Human) P06280
Entrez Gene ID: (Human) 2717, (Mouse) 11605
catalytic activity
hydrolase activity, hydrolyzing O-glycosyl compounds
alpha-galactosidase activity
receptor binding
protein binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
protein homodimerization activity
galactoside binding
raffinose alpha-galactosidase activity
galactosidase
carbohydrate metabolic process
lipid metabolic process
oligosaccharide metabolic process
glycoside catabolic process
negative regulation of nitric oxide biosynthetic process
glycosylceramide catabolic process
glycosphingolipid catabolic process
negative regulation of nitric-oxide synthase activity
metabolic process
bone mineralization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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