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Proteintech
KCNAB2 Polyclonal Antibody
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Product Details
17890-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNAB2 Fusion Protein Ag12096 (1-395 aa encoded by BC110351)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MYPESTTGS PARLSLRQTG SPGMIYSTRY GSPKRQLQFY RNLGKSGLRV SCLGLGTWVT FGGQITDEMA EQLMTLAYDN GINLFDTAEV YAAGKAEVVL GNIIKKKGWR RSSLVITTKI FWGGKAETER GLSRKHIIEG LKASLERLQL EYVDVVFANR PDPNTPMEET VRAMTHVINQ GMAMYWGTSR WSSMEIMEAY SVARQFNLTP PICEQAEYHM FQREKVEVQL PELFHKIGVG AMTWSPLACG IVSGKYDSGI PPYSRASLKG YQWLKDKILS EEGRRQQAKL KELQAIAERL GCTLPQLAIA WCLRNEGVSS VLLGASNADQ LMENIGAIQV RVRGPAGQRA HPSPSPVQCI LPGSSCVPGS VLGTQDAPVN HQSCAPGELA FQQEQT (1-395 aa encoded by B C110351)
Target Information
Kcnab2 is a voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hKvbeta2; K(+) channel subunit beta-2; KCNAB2; Kv-beta-2; Kvbeta2; Neuroimmune protein F5; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; unnamed protein product; Voltage-gated potassium channel subunit beta-2
Gene Aliases: AKR6A5; Ckbeta2; F5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; I2rf5; KCNA2B; KCNAB2; Kcnb3; KCNK2; KV-BETA-2
UniProt ID: (Human) Q13303, (Mouse) P62482, (Rat) P62483
Entrez Gene ID: (Human) 8514, (Mouse) 16498, (Rat) 29738
voltage-gated potassium channel activity
protein binding
alcohol dehydrogenase (NADP+) activity
potassium channel regulator activity
oxidoreductase activity
ion channel binding
methylglyoxal reductase (NADPH) (acetol producing) activity
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
aldo-keto reductase (NADP) activity
isocitrate dehydrogenase activity
mevaldate reductase activity
voltage-gated ion channel activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
hematopoietic progenitor cell differentiation
transport
ion transport
potassium ion transport
regulation of ion transmembrane transport
neuromuscular process
protein heterooligomerization
oxidation-reduction process
NADPH oxidation
regulation of potassium ion transmembrane transport
regulation of protein localization to cell surface
potassium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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