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Proteintech
ASIC1 Polyclonal Antibody
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Product Details
27235-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASIC1 Fusion Protein Ag25941 (464-528 aa encoded by NM_001095)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKLCRRGKC QKEAKRSSAD KGVALSLDDV KRHNPCESLR GHPAGMTYAA NILPHHPARG TFEDFTC (464-528 aa encoded by NM_001095)
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ACCN2 variant 3; acid sensing (proton gated) ion channel 1; acid sensing ion channel; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; Acid-sensing ionic channel; Amiloride-sensitive cation channel 2, neuronal; ASIC; ASIC1; BNaC2; Brain sodium channel 2; Cation channel, amiloride-sensitive, neuronal, 2; degenerin 2; hBNaC2; proton gated cation channel ASIC1; unnamed protein product
Gene Aliases: ACCN2; AI843610; ASIC; ASIC1; ASIC1a; B530003N02Rik; BNAC2
UniProt ID: (Human) P78348, (Mouse) Q6NXK8, (Rat) P55926
Entrez Gene ID: (Human) 41, (Mouse) 11419, (Rat) 79123
ion channel activity
cation channel activity
sodium channel activity
protein binding
ligand-gated sodium channel activity
ion gated channel activity
inorganic cation transmembrane transporter activity
pH-gated monoatomic ion channel activity
monovalent inorganic cation transmembrane transporter activity
acid-sensing ion channel activity
ion channel
behavioral fear response
response to amphetamine
ion transport
cation transport
sodium ion transport
calcium ion transport
neurotransmitter secretion
memory
associative learning
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of neurotransmitter secretion
sensory perception of sour taste
establishment of localization in cell
calcium ion transmembrane transport
cellular response to pH
inorganic cation transmembrane transport
regulation of postsynapse assembly
transport
monovalent inorganic cation transport
sensory perception of pain
protein homotrimerization
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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