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NeoBiotechnologies

Calcineurin A/PPP3CA Monoclonal Antibody (CALNA, 2353)

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Calcineurin A/PPP3CA Monoclonal Antibody (CALNA, 2353)

Product Details

5530-MSM2-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

CALNA, 2353

Immunogen

Recombinant full-length human Calcineurin A protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2CB; Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; unnamed protein product

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Gene Aliases: ACCIID; CALN; CALNA; CALNA1; CCN1; CNA; CNA1; DEE91; IECEE; IECEE1; PPP2B; PPP3CA

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UniProt ID: (Human) Q08209

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Entrez Gene ID: (Human) 5530

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity calcium ion binding protein binding calmodulin binding hydrolase activity enzyme binding calmodulin-dependent protein phosphatase activity metal ion binding protein dimerization activity ATPase binding
Process(es)
G1/S transition of mitotic cell cycle protein dephosphorylation protein import into nucleus calcium ion transport epidermis development positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression transition between fast and slow fiber cardiac muscle hypertrophy in response to stress dephosphorylation calcium-mediated signaling negative regulation of signaling keratinocyte differentiation positive regulation of cell migration calcineurin-NFAT signaling cascade multicellular organismal response to stress wound healing positive regulation of activated T cell proliferation T cell activation proteasome-mediated ubiquitin-dependent protein catabolic process skeletal muscle tissue regeneration positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter positive regulation of saliva secretion skeletal muscle fiber development dendrite morphogenesis negative regulation of dendrite morphogenesis modulation of synaptic transmission response to calcium ion excitatory postsynaptic potential regulation of cell proliferation involved in kidney morphogenesis peptidyl-serine dephosphorylation renal sodium ion absorption positive regulation of calcineurin-NFAT signaling cascade positive regulation of glomerulus development renal filtration calcineurin-mediated signaling postsynaptic modulation of chemical synaptic transmission negative regulation of angiotensin-activated signaling pathway positive regulation of angiotensin-activated signaling pathway positive regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of cardiac muscle hypertrophy in response to stress positive regulation of connective tissue replacement positive regulation of calcium ion import across plasma membrane negative regulation of calcium ion import across plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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