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Invitrogen
DDX41 Recombinant Rabbit Monoclonal Antibody (17H29L42)
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FIGURE: 1 / 4
DDX41 Antibody (703142) in ICC/IF
For immunofluorescence analysis, MCF-7 cells were fixed and permeabilized using ice cold 100% Acetone for detection of endogenous DDX41 using Anti-DDX41 Recombinant Rabbit Monoclonal Antibody (Product # 703142, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of DDX41 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifa... View More
Product Details
703142
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
17H29L42
Immunogen
Protein corresponding to human DDX41 [aa402-aa569]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Probable ATP-dependent RNA helicase DDX41 is a DEAD box protein characterized by the conserved motif Asp-Glu-Ala-Asp. It is required during post-transcriptional gene expression and may be involved in pre-mRNA splicing. Mutations affecting the gene can result in myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abstrakt; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DEAD box protein 41; DEAD box protein abstrakt homolog; DEAD-box protein abstrakt; Probable ATP-dependent RNA helicase DDX41; putative RNA helicase; unnamed protein product
Gene Aliases: ABS; DDX41; MPLPF
UniProt ID: (Human) Q9UJV9
Entrez Gene ID: (Human) 51428
mRNA splicing, via spliceosome
mRNA processing
apoptotic process
cell proliferation
RNA splicing
cell differentiation
positive regulation of type I interferon production
cellular response to interferon-beta
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
cGAS/STING signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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