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Bethyl Laboratories

hnRNP-U Polyclonal Antibody

View all (13) hnRNP U antibodies

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hnRNP-U Polyclonal Antibody

Product Details

IHC-00089

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 450 and 500 of human Heterogeneous Nuclear Ribonucleoprotein U.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Crab-eating macaque

Target Information

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: contains signal peptide domain; FLJ30202; FLJ37978; GRIP120; Heterogeneous nuclear ribonucleoprotein U; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); heterogenous nuclear ribonucleoprotein U; hnRNP U; HNRNPU antisense RNA 1; NCRNA00201; nuclear matrix protein sp120; Nuclear p120 ribonucleoprotein; p120; p120 nuclear protein; pp120; SAF-A; SAR-DNA binding protein of the nuclear scaffold; scaffold attachment factor A; Scaffold-attachment factor A; U211; unnamed protein product

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Gene Aliases: AA408410; AI256620; AL024194; AL024437; AW557595; C1orf199; C86794; DEE54; EIEE54; GRIP120; hnRNP U; HNRNPU; HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; Sp120; U21.1

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UniProt ID: (Human) Q00839, (Mouse) Q8VEK3

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Entrez Gene ID: (Human) 3192, (Mouse) 51810

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Function(s)
nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding TFIIH-class transcription factor binding DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity RNA binding double-stranded RNA binding single-stranded RNA binding mRNA 3'-UTR binding actin binding protein binding ATP binding poly(A) binding snRNA binding poly(C) RNA binding chromatin DNA binding poly(G) binding piRNA binding pre-mRNA binding identical protein binding ribonucleoprotein complex binding sequence-specific DNA binding macromolecular complex binding telomerase RNA binding RNA polymerase II C-terminal domain binding lncRNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding core promoter binding poly(A) RNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome osteoblast differentiation chromatin organization RNA processing mRNA processing regulation of mitotic cell cycle RNA splicing dosage compensation by inactivation of X chromosome regulation of gene expression positive regulation of macromolecule biosynthetic process mRNA metabolic process cell differentiation erythrocyte differentiation chromatin silencing by small RNA negative regulation of telomere maintenance via telomerase circadian regulation of gene expression negative regulation of kinase activity negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter mRNA stabilization rhythmic process cell division maintenance of protein location in nucleus cardiac muscle cell development random inactivation of X chromosome CRD-mediated mRNA stabilization cellular response to glucocorticoid stimulus positive regulation of brown fat cell differentiation dendritic transport of messenger ribonucleoprotein complex negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of mitotic spindle assembly regulation of chromatin organization positive regulation of attachment of mitotic spindle microtubules to kinetochore protein localization to spindle microtubule RNA localization to chromatin cellular response to leukemia inhibitory factor adaptive thermogenesis positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of stem cell proliferation negative regulation of stem cell differentiation positive regulation of cytoplasmic translation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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