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Invitrogen
PGRP-S Monoclonal Antibody (188C424)
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FIGURE: 1 / 2
PGRP-S Antibody (MA1-41044) in IHC (P)
Immunohistochemistry analysis of PGRP-S in formalin fixed paraffin-embedded (FFPE) human esophagus. Samples were incubated with PGRP-S monoclonal antibody (Product # MA1-41044) using a dilution of 20 µg/mL. The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with ... View More
Product Details
MA1-41044
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
188C424
Immunogen
KLH-conjugated synthetic peptide corresponding to amino acids 165-180 of human PGRP-S.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: mouse spleen lysate or protein.
Immunogen sequence: YVLKGHRDVQ RTLSPG
Target Information
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein (5). However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50-100 times higher than in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytokine tag7; MGC126894; MGC126896; Peptidoglycan recognition protein 1; Peptidoglycan recognition protein short; PGRP-S; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
Gene Aliases: PGLYRP; PGLYRP1; PGRP; PGRP-S; PGRPS; SBBI68; TAG7; Tasg7; TNFSF3L; UNQ639/PRO1269
UniProt ID: (Human) O75594, (Mouse) O88593
Entrez Gene ID: (Human) 8993, (Mouse) 21946
immune system process
immune response
signal transduction
peptidoglycan catabolic process
response to bacterium
detection of bacterium
killing of cells of other organism
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
defense response to bacterium
innate immune response
negative regulation of inflammatory response
defense response to Gram-positive bacterium
interaction with host
antimicrobial humoral immune response mediated by antimicrobial peptide
pattern recognition receptor signaling pathway
apoptotic process
growth of symbiont in host
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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