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Invitrogen
XRCC1 Monoclonal Antibody (33-2-5), Biotin
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Product Details
MA5-13409
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Rabbit
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
33-2-5
Immunogen
Recombinant human XRCC1 protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13409 targets XRCC1 in IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples.
The MA5-13409 immunogen is recombinant human XRCC1 protein.
Target Information
XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA repair protein XRCC1; DNA-repair protein; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; XRCC1
Gene Aliases: RCC; SCAR26; Xrcc-1; XRCC1
UniProt ID: (Human) P18887, (Rat) Q9ESZ0
Entrez Gene ID: (Human) 7515, (Rat) 84495
single strand break repair
DNA repair
base-excision repair
double-strand break repair
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
negative regulation of protein ADP-ribosylation
hippocampus development
response to hydroperoxide
telomeric DNA-containing double minutes formation
regulation of base-excision repair
negative regulation of protection from non-homologous end joining at telomere
response to hypoxia
response to organic substance
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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