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Invitrogen
Abl2 Monoclonal Antibody (1H1)
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Product Details
MA5-15586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H1
Immunogen
Purified recombinant fragment of ABL2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15586 targets ABL2 in indirect ELISA, IF and WB applications and shows reactivity with Human and mouse samples.
The MA5-15586 immunogen is purified recombinant fragment of ABL2 expressed in E. Coli.
MA5-15586 detects ABL2 which has a predicted molecular weight of approximately 128kDa.
Target Information
ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; abl2; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; tyrosine kinase ARG; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Gene Aliases: AA536808; ABL2; ABLL; ARG
UniProt ID: (Human) P42684
Entrez Gene ID: (Human) 27, (Mouse) 11352
nucleotide binding
magnesium ion binding
phosphotyrosine binding
actin monomer binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
enzyme activator activity
kinase activity
transferase activity
enzyme binding
manganese ion binding
metal ion binding
actin filament binding
receptor binding
transferase activity, transferring phosphorus-containing groups
cell adhesion
signal transduction
epidermal growth factor receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
regulation of endocytosis
regulation of cell adhesion
regulation of actin cytoskeleton organization
cellular response to oxidative stress
negative regulation of Rho protein signal transduction
exploration behavior
protein modification process
cellular response to retinoic acid
positive regulation of establishment of T cell polarity
regulation of cell motility
positive regulation of T cell migration
protein phosphorylation
phagocytosis
substrate-dependent cell migration, cell extension
actin filament organization
learning
visual learning
positive regulation of phospholipase C activity
phosphorylation
neuron remodeling
cell migration
cerebellum morphogenesis
negative regulation of cell-cell adhesion
actin cytoskeleton organization
positive regulation of protein binding
cellular protein localization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
alpha-beta T cell differentiation
platelet-derived growth factor receptor signaling pathway
dendrite morphogenesis
neuromuscular process controlling balance
actin filament bundle assembly
positive regulation of oxidoreductase activity
Bergmann glial cell differentiation
positive regulation of ERK1 and ERK2 cascade
dendritic spine maintenance
positive regulation of interleukin-2 secretion
positive regulation of interferon-gamma secretion
regulation of extracellular matrix organization
positive regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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