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Invitrogen

Beclin 1 Monoclonal Antibody (2A4)

Advanced Verification
1 Published Figure
3 References
View all (67) Beclin 1 antibodies

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Product Details

MA5-15825

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2A4

Immunogen

Purified recombinant fragment of human BECN1 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153717

Product Specific Information

MA5-15825 targets BECN1 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples.

The MA5-15825 immunogen is purified recombinant fragment of human BECN1 expressed in E. Coli.

MA5-15825 detects BECN1 which has a predicted molecular weight of approximately 60kDa.

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1-beta; beclin1-gamma; Coiled-coil myosin-like BCL2-interacting protein; partial ORF; putative; Protein GT197; testis secretory sperm-binding protein Li 215e; unnamed protein product

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Gene Aliases: ATG6; beclin1; BECN1; GT197; VPS30

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UniProt ID: (Human) Q14457

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Entrez Gene ID: (Human) 8678

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Function(s)
protein binding protein kinase binding protein binding, bridging ubiquitin protein ligase binding identical protein binding phosphatidylinositol 3-kinase binding GTPase binding binding, bridging
Process(es)
autophagosome assembly mitophagy response to hypoxia cytoplasmic pattern recognition receptor signaling pathway protein targeting to lysosome endocytosis autophagy apoptotic process cellular defense response cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression JNK cascade circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus response to iron(II) ion response to lead ion regulation of autophagy negative regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy macroautophagy regulation of macroautophagy response to nutrient levels regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to amino acid starvation phosphatidylinositol-3-phosphate biosynthetic process p38MAPK cascade cellular response to glucose starvation negative regulation of apoptotic process negative regulation of programmed cell death engulfment of apoptotic cell early endosome to late endosome transport late endosome to vacuole transport neuron development beta-amyloid metabolic process cell division defense response to virus response to other organism positive regulation of protein kinase B signaling SMAD protein signal transduction positive regulation of stress granule assembly protein-containing complex assembly cellular response to hydrogen peroxide cellular response to aluminum ion cellular response to copper ion cellular response to epidermal growth factor stimulus cellular response to oxygen-glucose deprivation autophagosome maturation response to mitochondrial depolarisation positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of autophagosome assembly negative regulation of lysosome organization positive regulation of autophagosome assembly positive regulation of intrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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