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Invitrogen

TNFAIP3 Recombinant Rabbit Monoclonal Antibody (SN07-31)

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TNFAIP3 Recombinant Rabbit Monoclonal Antibody (SN07-31)

Product Details

MA5-32292

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN07-31

Immunogen

Synthetic peptide within Human TNFAIP3 aa 491-540.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809577

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; unnamed protein product; Zinc finger protein A20

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Gene Aliases: A20; AIFBL1; AISBL; OTUD7C; TNFA1P2; TNFAIP3; Tnfip3

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UniProt ID: (Human) P21580, (Mouse) Q60769

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Entrez Gene ID: (Human) 7128, (Mouse) 21929

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Function(s)
protease binding DNA binding catalytic activity ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding peptidase activity cysteine-type peptidase activity zinc ion binding transferase activity hydrolase activity enzyme binding kinase binding identical protein binding ubiquitin binding metal ion binding Lys63-specific deubiquitinase activity K63-linked polyubiquitin binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity protein self-association coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity cysteine protease
Process(es)
B-1 B cell homeostasis response to molecule of bacterial origin immune system process regulation of germinal center formation negative regulation of chronic inflammatory response proteolysis apoptotic process inflammatory response cytoskeleton organization regulation of tumor necrosis factor-mediated signaling pathway cell migration protein deubiquitination positive regulation of Wnt signaling pathway negative regulation of protein ubiquitination response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K11-linked deubiquitination nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway regulation of cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein catabolic process negative regulation of bone resorption negative regulation of innate immune response negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host negative regulation of inflammatory response negative regulation of B cell activation regulation of vascular wound healing cellular response to hydrogen peroxide negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of osteoclast proliferation cellular response to oxygen-containing compound negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway marginal zone B cell differentiation negative regulation of granuloma formation regulation of immunoglobulin production metabolic process response to wounding negative regulation of autophagy negative regulation of NF-kappaB transcription factor activity negative regulation of heterotypic cell-cell adhesion regulation of innate immune response negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell death positive regulation of cellular protein catabolic process
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