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Invitrogen
RAB23 Monoclonal Antibody (427CT2.1.1)
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FIGURE: 1 / 4
RAB23 Antibody (MA5-37560) in ICC/IF
Immunocytochemistry/Immunofluorescent analysis of RAB23 in 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized U-2 OS cells using RAB23 Monoclonal Antibody (Product # MA5-37560) at a 1:25 dilution, followed by Dylight® 488-conjugated goat anti-mouse IgG (174309) secondary antibody at 1:200 dilution (green). Immunofluorescence image showing cytoplasm staining on U-2 OS cell line. Cytoplasmic actin is detected with Dylight® 554 Phalloidin at 1:100 dilution (red).The nuclear counter stain is DAPI (blue).
Product Details
MA5-37560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
427CT2.1.1
Immunogen
purified His-tagged RAB23 protein (fragment)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781H0695; MGC8900; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; Ras-related protein Rab-23; RP3-496N17.3; unnamed protein product
Gene Aliases: AW545388; HSPC137; opb; opb2; RAB23
UniProt ID: (Human) Q9ULC3
Entrez Gene ID: (Human) 51715, (Mouse) 19335
autophagosome assembly
intracellular protein transport
cellular defense response
anatomical structure morphogenesis
protein transport
negative regulation of protein import into nucleus
GTP metabolic process
system development
cilium morphogenesis
craniofacial suture morphogenesis
neural tube closure
transport
signal transduction
small GTPase mediated signal transduction
multicellular organism development
nervous system development
regulation of smoothened signaling pathway
spinal cord dorsal/ventral patterning
dorsal/ventral neural tube patterning
Rab protein signal transduction
cilium assembly
embryonic digit morphogenesis
negative regulation of transcription factor import into nucleus
negative regulation of proteolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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