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Invitrogen

TrkA Recombinant Rabbit Monoclonal Antibody (2A5)

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TrkA Recombinant Rabbit Monoclonal Antibody (2A5)

Product Details

MA5-38311

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2A5

Immunogen

A synthesized peptide derived from human TrkA (700-796aa)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Amount

80 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898226

Product Specific Information

This antibody has been tested in direct-ELISA

Target Information

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; trk tyrosine-specific protein kinase; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; unnamed protein product

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Gene Aliases: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA

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UniProt ID: (Human) P04629, (Mouse) Q3UFB7, (Rat) P35739

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Entrez Gene ID: (Human) 4914, (Mouse) 18211, (Rat) 59109

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development axon guidance learning or memory circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development positive regulation of neuron projection development peptidyl-tyrosine phosphorylation olfactory nerve development cell differentiation B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity neuron apoptotic process response to hydrostatic pressure response to electrical stimulus positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus multicellular organism development response to activity phosphorylation sensory perception of pain response to drug negative regulation of neuron death aging response to radiation response to ethanol
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