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Invitrogen
Artemin Recombinant Rabbit Monoclonal Antibody (24GB6845)
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FIGURE: 1 / 3
Artemin Antibody (MA5-56971) in ICC/IF
Immunocytochemistry analysis of Artemin in HepG2 cells. Sample was incubated with Artemin monoclonal (Product # MA5-56971) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Product Details
MA5-56971
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB6845
Immunogen
A synthesized peptide derived from human Artemin (aa 189-202)
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Amount
70 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Artemin; Enovin; glial cell line-derived (GDNF) neurotrophic factor family member; glial cell line-derived neurotrophic factor ligand family member; Neublastin
Gene Aliases: ART; ARTN; ENOVIN; EVN; NBN; neublastin
UniProt ID: (Human) Q5T4W7, (Rat) Q6AYE8, (Mouse) Q9Z0L2
Entrez Gene ID: (Human) 9048, (Rat) 362572, (Mouse) 11876
signal transduction
nervous system development
neuroblast proliferation
axon guidance
peripheral nervous system development
glial cell-derived neurotrophic factor receptor signaling pathway
induction of positive chemotaxis
Peyer's patch morphogenesis
lymphocyte migration into lymphoid organs
cell surface receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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