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Invitrogen
SOCS7 Recombinant Rabbit Monoclonal Antibody (24GB1820)
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FIGURE: 1 / 3
SOCS7 Antibody (MA5-57271) in ICC/IF
Immunocytochemistry analysis of SOCS7 in H9c2 cells. Sample was incubated with SOCS7 monoclonal (Product # MA5-57271) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Product Details
MA5-57271
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB1820
Immunogen
A synthesized peptide derived from human SOCS7 (aa 1-50)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NAP-4; Nck, Ash and phospholipase C binding protein; Nck, Ash and phospholipase C gamma-binding protein; NCK-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS-7; Suppressor of cytokine signaling 7
Gene Aliases: 2310063P06Rik; C85125; Cish7; NAP4; NCKAP4; SOCS6; SOCS7
UniProt ID: (Human) O14512, (Mouse) Q8VHQ2
Entrez Gene ID: (Human) 30837, (Rat) 287659, (Mouse) 192157
insulin receptor signaling pathway
negative regulation of signal transduction
protein ubiquitination
layer formation in cerebral cortex
intracellular signal transduction
reelin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of neuron migration
negative regulation of protein kinase activity
biological_process
cytokine-mediated signaling pathway
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
fat cell differentiation
negative regulation of JAK-STAT cascade
regulation of growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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