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Invitrogen

HDAC3 Polyclonal Antibody

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View all (33) HDAC3 antibodies

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HDAC3 Polyclonal Antibody

Product Details

PA1-862

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunocytochemistry (ICC/IF)

1:200
-

Immunoprecipitation (IP)

-
View 1 publication 1 publication

ChIP assay (ChIP)

1-3 µL
-
Product Specifications

Species Reactivity

Dog, Hamster, Human, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues C D(415) G D H D N D K E S D V E I(428) of human HDAC3.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2118393

Product Specific Information

PA1-862 detects histone deacetylase 3 (HDAC3) from canine, hamster, human and rat tissues and cells.

PA1-862 has been successfully used in Western blot and ChIP procedures. By Western blot, this antibody detects an ~48 kDa protein representing HDAC3 from HeLa cell lysate.

The PA1-862 immunogen is a synthetic peptide corresponding to residues C D(415) G D H D N D K E S D V E I(428) of human HDAC3. This immunizing peptide (Cat. # PEP-071) is available for use in neutralization and control experiments.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HD3; HDAC3; Histone deacetylase 3; histone deacetylase 3-like protein; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45

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Gene Aliases: HD3; HDAC3; KDAC3; RPD3; RPD3-2

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UniProt ID: (Human) O15379, (Rat) Q6P6W3

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Entrez Gene ID: (Dog) 478040, (Human) 8841, (Rat) 84578, (Chinese hamster) 100752639

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Function(s)
transcription corepressor binding DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding hydrolase activity deacetylase activity enzyme binding cyclin binding chromatin DNA binding protein deacetylase activity histone deacetylase binding GTPase binding NF-kappaB binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism protein decrotonylase activity histone decrotonylase activity protein de-2-hydroxyisobutyrylase activity protein lysine delactylase activity ubiquitin-specific protease binding transcription factor binding NAD-dependent histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific)
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation transcription, DNA-templated protein deacetylation regulation of mitotic cell cycle negative regulation of myotube differentiation histone deacetylation regulation of protein stability response to nutrient levels positive regulation of TOR signaling negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production circadian regulation of gene expression regulation of multicellular organism growth response to drug positive regulation of transcription factor import into nucleus negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of protein export from nucleus spindle assembly histone H3-K9 modification histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus cellular response to fluid shear stress response to dexamethasone positive regulation of type B pancreatic cell apoptotic process negative regulation of cardiac muscle cell differentiation establishment of mitotic spindle orientation in utero embryonic development chromatin organization transcription from RNA polymerase II promoter epidermis development response to xenobiotic stimulus gene expression positive regulation of protein ubiquitination protein modification process regulation of gene expression, epigenetic positive regulation of protein import into nucleus regulation of circadian rhythm negative regulation of apoptotic process rhythmic process random inactivation of X chromosome neural precursor cell proliferation establishment of skin barrier negative regulation of ferroptosis positive regulation of cold-induced thermogenesis DNA repair-dependent chromatin remodeling positive regulation of ferroptosis cornified envelope assembly
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