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Invitrogen
beta-1 Adrenergic Receptor Polyclonal Antibody
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FIGURE: 1 / 9
beta-1 Adrenergic Receptor Antibody (PA1-049) in ICC/IF
Immunofluorescent analysis of ADR-Beta-1 (green) in untreated HeLa cells. Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 15 minutes at room temperature. Cells were then blocked with 5% normal goat serum (Product # 31873) for 15 minutes at room temperature. Cells were probed with a rabbit polyclonal antibody recognizing ADR-Beta-1 (Product # PA1-049), at a dilution of 1:100 for at ... View More
Product Details
PA1-049
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Cat,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues H(394) G D R P R A S G C L A R A G(408) of mouse B1AR.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-049 detects beta-1 adrenergic receptor (B1AR) from , human, mouse, non-human primate, and rat tissues.
PA1-049 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~50.5 kDa band representing B1AR in mouse kidney membrane preparation. Immunofluorescence staining of B1AR in mouse kidney distal tubule with PA1-049 yields a pattern consistent with plasma membrane staining.
The PA1-049 immunogen is a synthetic peptide corresponding to residues H(394) G D R P R A S G C L A R A G(408) of mouse B1AR. This sequence is completely conserved between mouse and rat B1AR.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism. In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system. Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta 1-AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; beta-1-adrenergic receptor; cardiac beta adrenergic receptor
Gene Aliases: Adrb-1; ADRB1; ADRB1R; B1AR; beta-AR; BETA1AR; FNSS2; RATB1AR; RHR
UniProt ID: (Human) P08588, (Mouse) P34971, (Rat) P18090
Entrez Gene ID: (Human) 153, (Mouse) 11554, (Rat) 24925
G-protein coupled receptor activity
adrenergic receptor activity
beta-adrenergic receptor activity
beta1-adrenergic receptor activity
protein binding
PDZ domain binding
alpha-2A adrenergic receptor binding
protein heterodimerization activity
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
signal transducer activity
receptor signaling protein activity
Ras guanyl-nucleotide exchange factor activity
drug binding
dopamine binding
epinephrine binding
norepinephrine binding
G-protein coupled receptor
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to cold
heat generation
negative regulation of multicellular organism growth
fear response
positive regulation of MAPK cascade
regulation of circadian sleep/wake cycle, sleep
positive regulation of heart contraction
brown fat cell differentiation
regulation of postsynaptic membrane potential
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of cold-induced thermogenesis
positive regulation of the force of heart contraction by norepinephrine
positive regulation of systemic arterial blood pressure
glycogen catabolic process
apoptotic process
Rho protein signal transduction
cell-cell signaling
memory
positive regulation of heart rate
sensory perception of pain
positive regulation of cAMP biosynthetic process
protein localization to organelle
negative regulation of urine volume
wound healing
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
positive regulation of adenylate cyclase activity
negative regulation of smooth muscle contraction
positive regulation of saliva secretion
regulation of calcium ion transport
lipid homeostasis
inhibitory postsynaptic potential
positive regulation of cell growth involved in cardiac muscle cell development
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
positive regulation of renin secretion into blood stream
positive regulation of long-term synaptic potentiation
positive regulation of cation channel activity
aging
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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