Search

  • お問い合わせ一覧​
  • クイックオーダー

Invitrogen

SMAD6 Polyclonal Antibody

Advanced Verification
1 Published Figure
2 References
View all (18) SMAD6 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
SMAD6 Polyclonal Antibody

Product Details

PA1-41026

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL
-

Immunocytochemistry (ICC/IF)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Sheep, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide made to an internal portion of human SMAD6 (between amino acids 30-150).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2302345

Product Specific Information

This antibody is predicted to react with equine based on sequence homology.

Suggested positive control: HeLa or NIH-3T3 whole cell lysate.

Cross reacts with New World Monkey.

Target Information

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6

View more View less

Gene Aliases: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6

View more View less

UniProt ID: (Human) O43541, (Mouse) O35182

View more View less

Entrez Gene ID: (Sheep) 101103068, (Human) 4091, (Mouse) 17130, (Rat) 367100

View more View less

Function(s)
transcription regulatory region sequence-specific DNA binding chromatin binding protein binding ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding metal ion binding co-SMAD binding I-SMAD binding R-SMAD binding activin receptor binding type I activin receptor binding protein sequestering activity transcription regulator inhibitor activity RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity transcription regulatory region DNA binding molecular_function DNA-binding transcription factor gene-specific transcriptional regulator
Process(es)
ureteric bud development outflow tract septum morphogenesis heart valve development aortic valve morphogenesis mitral valve morphogenesis pulmonary valve morphogenesis ventricular septum development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter immune response zygotic specification of dorsal/ventral axis negative regulation of cell proliferation anatomical structure morphogenesis cell differentiation negative regulation of ossification BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway cell-substrate adhesion response to lipopolysaccharide negative regulation of activin receptor signaling pathway response to laminar fluid shear stress aorta development negative regulation of apoptotic process response to estrogen fat cell differentiation negative regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of SMAD protein import into nucleus SMAD protein signal transduction coronary vasculature development cellular response to growth factor stimulus transforming growth factor beta receptor superfamily signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter transcription, DNA-templated transforming growth factor beta receptor signaling pathway negative regulation of SMAD protein complex assembly intracellular signal transduction positive regulation of vasoconstriction negative regulation of vasodilation negative regulation of pathway-restricted SMAD protein phosphorylation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support