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Invitrogen
RAN Polyclonal Antibody
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FIGURE: 1 / 8
RAN Antibody (PA1-9092) in ICC/IF
Immunofluorescence analysis of RAN was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with RAN Polyclonal Antibody (Product # PA1-9092) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then with Rabbit anti-Goat IgG Heavy Chain, Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488 conjugate (Product # A27012) at a di... View More
Product Details
PA1-9092
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N terminus amino acids AAQGEPQVQFKLV (aa 2-14).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor-associated protein 24; ARA25; G protein; RAN/TC4; ARA24; GTP-binding nuclear protein Ran; GTPase Ran; guanosine triphosphatase Ran; member RAS oncogene family; OTTHUMP00000166078; OTTHUMP00000166102; RAN; RanGTPase; ras-like protein; Ras-like protein TC4; Ras-related nuclear protein; unnamed protein product
Gene Aliases: ARA24; Gsp1; OK/SW-cl.81; RAN; Rasl2-8; TC4
UniProt ID: (Human) P62826, (Mouse) P62827
Entrez Gene ID: (Human) 5901, (Mouse) 19384
nucleotide binding
magnesium ion binding
chromatin binding
RNA binding
GTPase activity
obsolete small monomeric GTPase activity
nuclear export signal receptor activity
protein binding
GTP binding
hydrolase activity
GDP binding
protein domain specific binding
macromolecular complex binding
cadherin binding
dynein intermediate chain binding
metal ion binding
protein heterodimerization activity
importin-alpha family protein binding
pre-miRNA binding
protein complex binding
poly(A) RNA binding
small GTPase
ribosomal subunit export from nucleus
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
mitotic sister chromatid segregation
mitotic cell cycle
glycolytic process
DNA metabolic process
protein import into nucleus
protein export from nucleus
nucleocytoplasmic transport
mitotic spindle organization
spermatid development
protein localization
protein transport
viral process
hippocampus development
actin cytoskeleton organization
protein complex localization
pre-miRNA export from nucleus
positive regulation of protein import into nucleus
GTP metabolic process
cell division
snRNA import into nucleus
cellular response to mineralocorticoid stimulus
protein localization to nucleolus
protein import into nucleus, translocation
transport
intracellular protein transport
cell cycle
mitotic nuclear division
signal transduction
small GTPase mediated signal transduction
positive regulation of protein binding
cellular protein localization
cellular protein complex localization
regulation of protein binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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