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Invitrogen
Phospho-LKB1 (Ser428) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-LKB1 (Ser428) Antibody (PA5-105004) in ICC/IF
Immunofluorescent analysis of Phospho-LKB1 (Ser428) in COS7 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% saponin, blocked with 10% serum (45 min, 37°C) incubated with Phospho-LKB1 (Ser428) polyclonal antibody (Product # PA5-105004) using a dilution of 1:400 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Product Details
PA5-105004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human STK11(Accession Q15831), corresponding to amino acid residues around phosphorylated Ser428.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of LKB1 only when phosphorylated at Serine 428.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; STK11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11; unnamed protein product
Gene Aliases: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11
UniProt ID: (Human) Q15831, (Mouse) Q9WTK7
Entrez Gene ID: (Human) 6794, (Mouse) 20869
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
protein dephosphorylation
autophagy
apoptotic process
cellular response to DNA damage stimulus
signal transduction
spermatogenesis
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
peptidyl-threonine phosphorylation
establishment of cell polarity
regulation of Wnt signaling pathway
cell differentiation
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
protein localization to nucleus
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of axonogenesis
T cell receptor signaling pathway
Golgi localization
regulation of cell cycle
regulation of protein kinase B signaling
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
G1 to G0 transition
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of canonical Wnt signaling pathway
dendrite extension
negative regulation of cold-induced thermogenesis
positive regulation of protein localization to nucleus
positive regulation of vesicle transport along microtubule
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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