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Invitrogen

Phospho-PKC delta/theta (Ser643, Ser676) Polyclonal Antibody

View all (3) PKC delta/theta antibodies

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Phospho-PKC delta/theta (Ser643, Ser676) Polyclonal Antibody

Product Details

PA5-110147

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S643 of human PKCδ/θPRKCD (NP_0013416051)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Amount

24 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2855558

Product Specific Information

Immunogen sequence: RLSYS

Target Information

PRKCD (Protein Kinase C Delta) is a Protein Coding gene. Diseases associated with PRKCD includeAutoimmune Lymphoproliferative Syndrome, Type IiiandSystemic Lupus Erythematosus 16. Among its related pathways areRole of Calcineurin dependent NFAT signaling in lymphocytesandWnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene includetransferase activity, transferring phosphorus containing groupsandprotein tyrosine kinase activity. An important paralog of this gene isPRKCQ (PKC theta).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: nPKC-delta; nPKC-theta; PKC theta; PKCdeltaVIII; Protein kinase C delta type; protein kinase C delta variant IX; protein kinase C delta VIII; Protein kinase C theta type; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; SDK-1; Tyrosine-protein kinase PRKCD; unnamed protein product

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Gene Aliases: A130035A12Rik; AI385711; ALPS3; AW494342; CVID9; D14Ertd420e; MAY1; nPKC-delta; nPKC-theta; PKC-0; PKC-theta; PKC[d]; PKCD; PKCdelta; Pkcq; PKCtheta; PRKCD; PRKCQ; PRKCT

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UniProt ID: (Human) Q05655, (Human) Q04759, (Mouse) P28867, (Mouse) Q02111

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Entrez Gene ID: (Human) 5580, (Human) 5588, (Mouse) 18753, (Mouse) 18761

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity zinc ion binding kinase activity transferase activity enzyme binding protein kinase binding protein tyrosine kinase activator activity insulin receptor substrate binding metal ion binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups TIR domain binding non-receptor serine/threonine protein kinase
Process(es)
protein phosphorylation apoptotic process cellular response to DNA damage stimulus signal transduction intrinsic apoptotic signaling pathway in response to oxidative stress immunoglobulin mediated immune response peptidyl-serine phosphorylation peptidyl-threonine phosphorylation termination of signal transduction negative regulation of actin filament polymerization positive regulation of endodeoxyribonuclease activity positive regulation of superoxide anion generation regulation of actin cytoskeleton organization negative regulation of glial cell apoptotic process cellular response to UV intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis B cell proliferation neutrophil activation positive regulation of protein import into nucleus defense response to bacterium negative regulation of apoptotic process negative regulation of MAPK cascade regulation of mRNA stability post-translational protein modification negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response protein stabilization positive regulation of DNA metabolic process negative regulation of filopodium assembly cell chemotaxis cellular response to hydrogen peroxide protein kinase C signaling cellular response to fatty acid cellular response to hydroperoxide negative regulation of platelet aggregation cellular senescence phospholipase C/protein kinase C signal transduction positive regulation of phospholipid scramblase activity cellular response to angiotensin regulation of ceramide biosynthetic process positive regulation of ceramide biosynthetic process positive regulation of glucosylceramide catabolic process positive regulation of sphingomyelin catabolic process positive regulation of apoptotic signaling pathway regulation of cell growth immune system process regulation of transcription, DNA-templated membrane protein ectodomain proteolysis inflammatory response axon guidance positive regulation of telomere maintenance positive regulation of interleukin-17 production positive regulation of interleukin-2 production positive regulation of interleukin-4 production CD4-positive, alpha-beta T cell proliferation Fc-epsilon receptor signaling pathway T cell activation positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity negative regulation of T cell apoptotic process regulation of platelet aggregation positive regulation of T-helper 17 type immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of T-helper 2 cell activation response to oxidative stress cell cycle aspartate transport phosphorylation interleukin-10 production interleukin-12 production collagen metabolic process cellular response to oxidative stress positive regulation of protein dephosphorylation regulation of phosphorylation positive regulation of apoptotic process positive regulation of MAP kinase activity negative regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of glucose import protein autophosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive regulation of response to DNA damage stimulus regulation of G2/M transition of mitotic cell cycle positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus positive regulation of interleukin-2 biosynthetic process positive regulation of protein secretion positive regulation of filopodium assembly positive regulation of stress fiber assembly
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