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Invitrogen

BMPR2 Polyclonal Antibody

View all (13) BMPR2 antibodies

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BMPR2 Polyclonal Antibody

Product Details

PA5-11863

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Flow Cytometry (Flow)

1:10-1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2259033

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4; unnamed protein product

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Gene Aliases: BMPR-II; BMPR2; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK

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UniProt ID: (Human) Q13873

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Entrez Gene ID: (Human) 659

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity protein binding ATP binding kinase activity activin receptor activity, type II transferase activity growth factor binding BMP binding cadherin binding metal ion binding BMP receptor activity protein tyrosine kinase binding
Process(es)
regulation of cell growth blood vessel development osteoblast differentiation mesoderm formation maternal placenta development endothelial cell proliferation vasculature development lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure outflow tract septum morphogenesis outflow tract morphogenesis aortic valve development pulmonary valve development atrioventricular valve morphogenesis mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion development negative regulation of cell proliferation involved in heart valve morphogenesis transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell proliferation cellular response to starvation tissue development anterior/posterior pattern specification positive regulation of gene expression positive regulation of epithelial cell migration regulation of lung blood pressure cell differentiation proteoglycan biosynthetic process negative regulation of cell growth lung development positive regulation of bone mineralization BMP signaling pathway activin receptor signaling pathway positive regulation of locomotion regulation of cell proliferation positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter lung alveolus development negative regulation of smooth muscle cell proliferation cardiac muscle tissue development positive regulation of axon extension involved in axon guidance stem cell differentiation negative regulation of muscle cell differentiation retina development in camera-type eye limb development endochondral bone morphogenesis positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis atrial septum morphogenesis lung vasculature development lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye pharyngeal arch artery morphogenesis cellular response to growth factor stimulus cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation semi-lunar valve development regulation of multicellular organismal development
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