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Invitrogen

VHL Polyclonal Antibody

View all (19) VHL antibodies

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VHL Polyclonal Antibody

Product Details

PA5-13487

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:25
-

Immunocytochemistry (ICC/IF)

1:25
-

Flow Cytometry (Flow)

1:25
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 43-71 amino acids from the N-terminal region of human VHL
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2215945

Product Specific Information

This antibody is predicted to react with rat based on sequence homology.

Target Information

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: elongin binding protein; Protein G7; pVHL; unnamed protein product; VHL19; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

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Gene Aliases: HRCA1; pVHL; RCA1; VHL; VHL1; Vhlh

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UniProt ID: (Human) P40337, (Mouse) P40338

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Entrez Gene ID: (Human) 7428, (Mouse) 22346

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Function(s)
obsolete transcription elongation regulator activity ubiquitin-protein transferase activity protein binding enzyme binding binding, bridging protein serine/threonine kinase binding DNA-binding transcription factor binding protein binding, bridging involved in substrate recognition for ubiquitination transcription factor binding protein complex binding ubiquitin protein ligase activity ubiquitin-protein ligase
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis response to hypoxia regulation of transcription, DNA-templated proteolysis negative regulation of cell proliferation negative regulation of signal transduction regulation of gene expression negative regulation of autophagy negative regulation of macromolecule biosynthetic process negative regulation of gene expression protein ubiquitination negative regulation of transcription elongation from RNA polymerase II promoter negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cell differentiation positive regulation of transcription, DNA-templated negative regulation of JAK-STAT cascade protein stabilization cellular response to hypoxia regulation of cellular response to hypoxia negative regulation of TORC1 signaling amyloid fibril formation angiogenesis type B pancreatic cell differentiation pancreatic A cell differentiation NLS-bearing protein import into nucleus proteasomal protein catabolic process protein transport protein catabolic process neuron differentiation extracellular matrix organization regulation of catecholamine metabolic process blood vessel endothelial cell migration negative regulation of endothelial cell differentiation protein heterooligomerization negative regulation of transcription from RNA polymerase II promoter in response to hypoxia regulation of thymocyte apoptotic process negative regulation of thymocyte apoptotic process negative regulation of hypoxia-inducible factor-1alpha signaling pathway regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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