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Invitrogen

PDGF-B Polyclonal Antibody

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PDGF-B Polyclonal Antibody

Product Details

PA5-19524

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1:150
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human PDGF B.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980265

Product Specific Information

This antibody is predicted to react with rat and cow based on sequence homology.

Store antibody at 4°C for 1-2 weeks. For long-term storage, store at -20°C.

Target Information

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: becaplermin; c-sis; epididymis secretory sperm binding protein; orf 2; PDGF subunit B; PDGF, B chain; PDGF-2; PDGFB; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Proto-oncogene c-Sis; unnamed protein product

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Gene Aliases: c-sis; IBGC5; PDGF-2; PDGF-B; PDGF2; PDGFB; SIS; SSV

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UniProt ID: (Human) P01127, (Mouse) P31240

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Entrez Gene ID: (Human) 5155, (Mouse) 18591

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Function(s)
platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity superoxide-generating NADPH oxidase activator activity chemoattractant activity identical protein binding protein homodimerization activity protein heterodimerization activity receptor agonist activity platelet-derived growth factor binding receptor binding growth factor
Process(es)
angiogenesis embryonic placenta development positive regulation of endothelial cell proliferation monocyte chemotaxis positive regulation of glomerular filtration protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart development positive regulation of cell proliferation response to wounding gene expression regulation of gene expression negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation positive regulation of macromolecule biosynthetic process positive regulation of gene expression negative regulation of gene expression positive regulation of cell-substrate adhesion smooth muscle adaptation positive regulation of smooth muscle cell migration peptidyl-tyrosine phosphorylation hemopoiesis positive regulation of cell migration positive regulation of protein autophosphorylation intracellular signal transduction interleukin-18-mediated signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus paracrine signaling positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive chemotaxis positive regulation of chemotaxis regulation of multicellular organismal process positive regulation of cell division positive regulation of protein kinase B signaling cell chemotaxis positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to mycophenolic acid positive regulation of glomerular mesangial cell proliferation metanephric glomerular mesangial cell development reactive oxygen species metabolic process positive regulation of calcium ion import positive regulation of hyaluronan biosynthetic process positive regulation of intracellular signal transduction negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular smooth muscle cell dedifferentiation positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process positive regulation of metanephric mesenchymal cell migration substrate-dependent cell migration multicellular organism development synapse assembly positive regulation of phosphatidylinositol 3-kinase signaling neuron remodeling peptidyl-serine phosphorylation glial cell development cell projection assembly actin cytoskeleton organization negative regulation of cell migration negative regulation of protein binding activation of protein kinase activity activation of protein kinase B activity positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway eye photoreceptor cell development positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of DNA replication positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of vasoconstriction negative regulation of vasodilation positive regulation of mitotic cell cycle, embryonic blood vessel morphogenesis regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation retina development in camera-type eye branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis cardiac vascular smooth muscle cell differentiation positive regulation of protein tyrosine kinase activity retina vasculature development in camera-type eye metanephric glomerular mesangial cell proliferation involved in metanephros development
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