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Invitrogen

TLR9 Polyclonal Antibody

View all (39) TLR9 antibodies

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Product Details

PA5-27258

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide encompassing a sequence within the Extracellular domain of human TLR9. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Amount

40 µg

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544734

Product Specific Information

Recommended positive controls: THP-1, Recombinant TLR9 protein.

Predicted reactivity: Rhesus Monkey (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform

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Gene Aliases: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96, (Mouse) Q9EQU3

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Entrez Gene ID: (Human) 54106, (Mouse) 81897

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Function(s)
interleukin-1 receptor binding siRNA binding pattern recognition receptor activity protein homodimerization activity unmethylated CpG binding transmembrane signaling receptor activity protein binding
Process(es)
microglial cell activation regulation of protein phosphorylation toll-like receptor signaling pathway response to molecule of bacterial origin immune system process regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway inflammatory response immune response signal transduction I-kappaB phosphorylation response to virus positive regulation of autophagy positive regulation of gene expression maintenance of gastrointestinal epithelium negative regulation of NF-kappaB transcription factor activity tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus positive regulation of nitric-oxide synthase biosynthetic process negative regulation of calcium-transporting ATPase activity positive regulation of cytokine production activation of innate immune response positive regulation of immunoglobulin production I-kappaB kinase/NF-kappaB signaling male gonad development positive regulation of B cell proliferation positive regulation of type I interferon production detection of molecule of bacterial origin positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of toll-like receptor 9 signaling pathway defense response to bacterium positive regulation of MAPK cascade regulation of B cell differentiation positive regulation of JNK cascade positive regulation of B cell activation negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to metal ion defense response to other organism endolysosomal toll-like receptor signaling pathway cellular response to chloroquine positive regulation of intestinal epithelial cell development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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