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Invitrogen
DLD Polyclonal Antibody
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Product Details
PA5-27367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DLD. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, mouse brain, PC-12, Rat2.
Predicted reactivity: Mouse (96%), Rat (96%), Xenopus laevis (94%), Dog (98%), Pig (99%), Chicken (93%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: branched chain alpha-keto acid dehydrogenase complex subunit E3; diaphorase; Dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoamide dehydrogenase precursor; Dihydrolipoyl dehydrogenase, mitochondrial; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; epididymis secretory sperm binding protein; Glycine cleavage system L protein; glycine cleavage system protein L; lipoamide dehydrogenase; lipoamide dehydrogenase precursor old gene name 'LAD'; lipoamide reductase; lipoyl dehydrogenase; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PH; PHE 3; pyruvate dehydrogenase complex subunit E3, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex, glycine cleavage system protein L; unnamed protein product
Gene Aliases: DLD; DLDD; DLDH; E3; GCSL; LAD; OGDC-E3; PHE3
UniProt ID: (Human) P09622, (Rat) Q6P6R2, (Mouse) O08749
Entrez Gene ID: (Human) 1738, (Rat) 298942, (Mouse) 13382
dihydrolipoyl dehydrogenase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
flavin adenine dinucleotide binding
mercury (II) reductase activity
lipoamide binding
mercury ion binding
NADP binding
NAD binding
oxidoreductase
acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
2-oxoglutarate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
gastrulation
branched-chain amino acid catabolic process
regulation of membrane potential
sperm capacitation
2-oxoglutarate decarboxylation to succinyl-CoA
branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
aging
lipoate metabolic process
cell redox homeostasis
detoxification of mercury ion
dihydrolipoamide metabolic process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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