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Invitrogen
CNTFR Polyclonal Antibody
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FIGURE: 1 / 1
CNTFR Antibody (PA5-96193) in WB
Western blot analysis of CNTFR in extracts of various cell lines. Samples were incubated with CNTFR Polyclonal antibody (Product # PA5-96193) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-96193
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_6716931)
Conjugate
Form
Liquid
Concentration
0.91 mg/mL
Amount
91 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FHRDSWHLRH QVLLHVGLPP REPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGS
Positive Samples: U-87MG, HeLa, Mouse brain, Mouse heart, Rat testis; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor
Target Information
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR alpha; CNTFR-alpha; MGC1774; unnamed protein product
Gene Aliases: CNTFR; Cntfralpha
UniProt ID: (Human) P26992, (Rat) Q08406, (Mouse) O88507
Entrez Gene ID: (Human) 1271, (Rat) 313173, (Mouse) 12804
suckling behavior
brainstem development
signal transduction
nervous system development
sex differentiation
positive regulation of cell proliferation
interleukin-11-mediated signaling pathway
negative regulation of neuron apoptotic process
skeletal muscle organ development
ciliary neurotrophic factor-mediated signaling pathway
motor neuron apoptotic process
negative regulation of motor neuron apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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