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Gibco
Human Eotaxin-3 (CCL26) Recombinant Protein, PeproTech®
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Product Details
300-48-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Bacteria,
Human,
Mouse
Expression System
E. coli
Amino acid sequence
TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Molecular weight
8.4 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to chemoattract human CCR3/HEK293 cells. The maximum activity was achieved at 2ug/ml.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Amount
100 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Eotaxin-3 is a small cytokine belonging to the CC chemokine family that is also called CCL26, Chemokine (C-C motif) ligand 26. Chemokines play pivotal roles in health and disease by controlling migration and tissue localization of specific types of cells expressing their cognate receptors. Eotaxin-3 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. This gene for chemokine is located on human chromosome 7. Eotaxin-3 induced migration of eosinophils and basophils only at a 10-fold higher concentration than eotaxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CC chemokine IMAC; CC chemokine; macrophage inflammatory protein-4alpha; MIP-4alpha; chemokine (C-C motif) ligand 26; chemokine N1; eotaxin-3; Eotaxin3; macrophage inflammatory protein 4-alpha; MGC126714; MIP-4-alpha; PRO242; SCYA26MIP-4-alpha; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; thymic stroma chemokine-1; TSC-1; CC chemokine; UNQ216
Gene Aliases: IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1
UniProt ID: (Human) Q9Y258
Entrez Gene ID: (Human) 10344
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