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Invitrogen
Human PIWIL2 Synthetic Peptide
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Product Details
PEP-1384
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human PIWI-L2.
PEP-1384 can be used as a blocking peptide with polyclonal antibody PA5-34341.
Target Information
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 80; CT80; PIWI-L2; piwi-like 2; Piwi-like protein 2; PIWIL2; piwil2-like protein; PL2L106; PL2L80A; testicular tissue protein Li 141; unnamed protein product
Gene Aliases: CT80; HILI; mili; PIWIL1L; PIWIL2
UniProt ID: (Human) Q8TC59
Entrez Gene ID: (Human) 55124
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