Chromatin immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a particular protein of interest. This technique gives a picture of the protein-DNA interactions that occur inside the nucleus of living cells or tissues. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states.

ChIP-Seq on the 5500xl Genetic Analyzer

Protein DNAProteins bound to DNA can impact the expression of genes, as well as the accessibility and packaging of DNA.

Unlike traditional microarrays, our ChIP-Seq technology offers you a way to study these interactions in an unbiased, hypothesis-free manner. Protein–DNA complexes are isolated by chromatin-immunoprecipitation and characterized by sequencing the associated DNA.
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ChIP-Seq Sample Prep for Next Generation Sequencing

Protein DNA

Chromatin immunoprecipitation (ChIP) is a method used to determine the location of DNA binding sites on the genome for a particular protein of interest. This technique gives a picture of the protein-DNA interactions that occur inside the nucleus of living cells or tissues. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states.
Learn more

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Next-Generation Sequencing Support Center
Find tips, troubleshooting help, and resources for your next-generation sequencing applications.

For Research Use Only. Not for use in diagnostic procedures.