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Proteintech
CD43 Monoclonal Antibody (W3/13)
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Product Details
65237-1-IG
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
W3/13
Immunogen
Rat thymocyte membrane glycoproteins
Conjugate
Form
Liquid
Amount
500 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Target Information
CD43, also known as leukosialin or sialophorin, is a transmembrane mucin-like protein characterized by a high negative charge. It is expressed on the surface of most hematopoietic cells, excluding resting B lymphocytes. CD43 serves both adhesive and anti-adhesive functions, contributing to a repulsive barrier that can interfere with cellular adhesion while also promoting leukocyte aggregation in certain contexts. CD43 is involved in the activation of T cells, B cells, NK cells, and monocytes. Its expression decreases upon activation due to proteolytic processing. The counter-receptor for CD43 is CD169/SIGLEC-1, which is expressed on macrophages. CD43 interacts with actin-binding proteins ezrin and moesin, playing a regulatory role in remodeling T-cell morphology and regulating cell-cell interactions during lymphocyte traffic. It enhances LFA-1 adhesiveness while counteracting LFA-1 induction via other receptors. CD43 signaling induces the functionally active tumor suppressor p53 protein, but in cases of p53 and ARF deficiency, it can promote tumor proliferation and viability. CD43 is an important modulator of leukocyte functions, with dysfunctions associated with diseases such as Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leukocyte sialoglycoprotein; leukosialin; leukosianin; sialophorin gpL115; W3/13 antigen
Gene Aliases: Cd43; gpL115; Lsn; Lsn1
Entrez Gene ID: (Rat) 24796
response to protozoan
negative regulation of type IV hypersensitivity
positive regulation of protein phosphorylation
chronic inflammatory response
negative regulation of cell adhesion
cell surface receptor signaling pathway
T cell costimulation
positive regulation of T cell proliferation
monocyte activation
negative regulation of T cell proliferation
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative thymic T cell selection
regulation of defense response to virus
regulation of immune response
negative regulation of T cell activation
thymocyte aggregation
apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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