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MECP2 Monoclonal Antibody (N227/21), FL650

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MECP2 Monoclonal Antibody (N227/21), FL650

Product Details

75-273-FL650

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N227/21

Immunogen

Synthetic peptide amino acids 157-169 of human MECP2 (accession number P51608).
View immunogen

Conjugate

FL650 FL650 FL650

Excitation/Emission Max

655/676 nm

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Sequence of this protein is as follows: FTVTG[dime thyl-R]GSP SRRE

Target Information

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686A24160; MeCp-2 protein; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Methyl-CpG-binding protein 2; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product

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Gene Aliases: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10

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UniProt ID: (Human) P51608, (Mouse) Q9Z2D6, (Rat) Q00566

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Entrez Gene ID: (Human) 4204, (Mouse) 17257, (Rat) 29386

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Function(s)
nucleic acid binding DNA binding chromatin binding transcription corepressor activity RNA binding mRNA binding protein binding methyl-CpG binding double-stranded methylated DNA binding siRNA binding binding, bridging histone reader activity molecular condensate scaffold activity promoter-specific chromatin binding four-way junction DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding poly(A) RNA binding unmethylated CpG binding protein N-terminus binding DNA metabolism protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process regulation of transcription from RNA polymerase II promoter glutamine metabolic process cellular biogenic amine metabolic process Notch signaling pathway chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization glucocorticoid metabolic process cell proliferation associative learning adult locomotory behavior visual learning post-embryonic development gene expression regulation of gene expression negative regulation of gene expression glial cell proliferation dendrite development negative regulation of angiogenesis proprioception sensory perception of pain cerebellum development ventricular system development neuron differentiation neuron projection development heterochromatin assembly cardiolipin metabolic process multicellular organismal response to stress social behavior regulation of gene expression, epigenetic neuron maturation negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration hypermethylation of CpG island negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylcholine metabolic process regulation of synaptic plasticity cell development catecholamine secretion neuromuscular process controlling posture neuromuscular process negative regulation of developmental process negative regulation of smooth muscle cell differentiation response to other organism excitatory postsynaptic potential positive regulation of glial cell proliferation long-term synaptic potentiation genetic imprinting positive regulation of microtubule nucleation trans-synaptic signaling by BDNF regulation of multicellular organismal development mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation pathogenesis embryo development histone methylation histone acetylation negative regulation of histone methylation negative regulation of histone acetylation regulation of DNA methylation negative regulation of astrocyte differentiation positive regulation of synapse assembly heart development response to ionizing radiation response to lead ion response to organic cyclic compound response to estradiol
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