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Invitrogen
CD105 Monoclonal Antibody (MEM-226), FITC
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FIGURE: 1 / 9
CD105 Antibody (MA1-19594) in Flow
Separation of HUVEC cells stained using anti-human CD105 (MEM-226) FITC Monoclonal antibody (Product # MA1-19594), 20 µL reagent per million cells in 100 µL of cell suspension (red-filled) from unstained HUVEC cells (black-dashed) in flow cytometry analysis (surface staining) of HUVEC cells.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-19594
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MEM-226
Immunogen
Recombinant vaccinia virus containing the human CD105 cDNA.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.03 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105 antigen; circulating isoform of endoglin TGF-beta receptor type III; endoglin precursor; ORW; soluble endoglin; TGF-beta receptor type III family; unnamed protein product
Gene Aliases: END; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022, (Rat) 497010
transmembrane signaling receptor activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
coreceptor activity
receptor activator activity
type I transforming growth factor beta receptor binding
BMP binding
identical protein binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
heart looping
sprouting angiogenesis
positive regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
heart development
response to xenobiotic stimulus
positive regulation of gene expression
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
negative regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of collagen biosynthetic process
dorsal aorta morphogenesis
wound healing
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
positive regulation of protein kinase B signaling
atrial cardiac muscle tissue morphogenesis
cell chemotaxis
bone development
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
extracellular matrix constituent secretion
detection of hypoxia
cellular response to mechanical stimulus
response to transforming growth factor beta
endocardial cushion to mesenchymal transition
vascular smooth muscle cell development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of vascular smooth muscle cell differentiation
cardiac jelly development
atrioventricular canal morphogenesis
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of cell proliferation involved in heart morphogenesis
regulation of cell adhesion
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of cell proliferation
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