FIGURE: 1 / 3
Immunogen sequence: DLEIAAEFR LSAPVRDLLD VLKSKQYVKV QIPGLENLQM FVPDTLAEEK SIILQLLNAA AGKDCSKDSD DVLIDAYLLL TKHGDRARDS EDSWGTWEAQ PVKVVPQVET VDTLRSMQVD NLLLVVMQSA HLTIQRKAFQ QSIEGLMTLC QEQTSSQPVI AKALQQLKND ALELCNRISN AIDRVDHMFT SEFDAEVDES ESVTLQQYYR EAMIQGYNFG FEYHKEVVRL MSGEFRQKIG DKYISFARKW MNYVLTKCES GRGTRPRWAT QGFDFLQAIE PAFISALPED DFLSLQALMN ECIGHVIGKP HSPVTGLYLA IHRNSPRPMK VPRCHSDPPN PHLIIPTPEG F (825-1174 aa encoded by BC146770)
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
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Protein Aliases: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; predicted protein of HQ0412; PRKMK4; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; T-associated sex reversal
Gene Aliases: D17Rp17; D17Rp17e; KIAA0213; MAP3K4; MAPKKK4; Mek4b; MEKK 4; MEKK4; mKIAA0213; MTK1; PRO0412; RP17; Rp17a; Tas
Molecular Function: non-receptor serine/threonine protein kinase