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CD1c Monoclonal Antibody (L161), PE
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Product Details
PE-65176100TEST
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
L161
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
10 µL/Test
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
CD1c is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. This family of proteins is involved in the presentation of lipid and glycolipid antigens, both of self and microbial origin, to T cells during the adaptive immune response. CD1c is expressed on some circulating and marginal zone B cells, as well as in lymph nodes and germinal centers. It plays a crucial role in presenting lipid antigens, such as microbial fatty acids, to effector T cells. The protein encoded by the CD1c gene localizes to late endosomes and lysosomes, utilizing a tyrosine-based motif in its cytoplasmic tail for targeting. Vesicular acidification is required for CD1c to bind lipid antigens effectively. The human genome contains five CD1 family genes organized in a cluster on chromosome 1, with each member differing in cellular localization and specificity for particular lipid ligands. CD1c undergoes alternative splicing, resulting in three different isoforms: soluble, membrane-bound, and cytoplasmic/soluble isoforms, highlighting its functional diversity in immune processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD1C; CD1c antigen precursor; CD1C antigen, c polypeptide; cortical thymocyte antigen CD1C; differentiation antigen CD1-alpha-3; RP11-101J8.3; T-cell surface glycoprotein CD1c; unnamed protein product
Gene Aliases: BDCA1; CD1; CD1A; CD1C; R7
UniProt ID: (Human) P29017
Entrez Gene ID: (Human) 911
positive regulation of T cell mediated cytotoxicity
adaptive immune response
T cell activation involved in immune response
immune system process
immune response
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
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