Abbreviations and Acronyms
Definitions | |
---|---|
HLC | Heavy-light chain |
IFE | Immunofixation |
MM | Multiple myeloma |
IMWG | International Myeloma Working Group |
SPEP | Serum protein electrophoresis |
UPEP | urine protein electrophoresis |
If a patient with myeloma produces monoclonal protein measurable by serum protein electrophoresis (SPEP) (≥10 g/L (1 g/dL)) or urine protein electrophoresis (UPEP) (≥200 mg/24-hour urine), then the International Myeloma Working Group (IMWG) recommends regular monitoring with these methods.1
If a patient is not measurable by these methods at baseline, but has an involved serum free light chain (sFLC) of at least 100 mg/L and an abnormal sFLC ratio, the patient may be monitored by sFLC according to IMWG guidelines.1
Serum free light chain (sFLC) assays can be used alongside electrophoretic methods even when monoclonal protein measurable by serum protein electrophoresis (SPEP) (≥10 g/L (1 g/dL)) or urine protein electrophoresis (UPEP) (≥200 mg/24-hour urine).
to monitor the changes in the involved immunoglobulin by their unique quantification of IgG, IgA and IgM heavy and light chain isotypes.3,4,5 These techniques offer improved analytical sensitivity compared to traditional SPEP and IFE methods and may aid in the monitoring of patients over time.3,4
Freelite® and Hevylite® assays should be used in conjunction with SPEP and IFE as they offer clinicians and laboratory professionals advanced monitoring tools to allow objective quantification of monoclonal proteins, and measurement at lower concentrations than traditional methods, for the best possible care for their patients6, 7.
Freelite and Hevylite are registered trademarks of The Binding Site Group Ltd (Birmingham, UK) in certain countries
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Definitions | |
---|---|
HLC | Heavy-light chain |
IFE | Immunofixation |
MM | Multiple myeloma |
IMWG | International Myeloma Working Group |
SPEP | Serum protein electrophoresis |
UPEP | urine protein electrophoresis |