This TEK (TIE2) Y897S recombinant human protein (771–end) was expressed in insect cells. TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues. TEK (TIE2) Y897S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service