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Invitrogen

CD41/CD61 Monoclonal Antibody (PAC-1), Alexa Fluor™ 488

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CD41/CD61 Monoclonal Antibody (PAC-1), Alexa Fluor™ 488

Product Details

MA5-44123

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

4 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

PAC-1

Immunogen

Human platelets
3D Epitope / Immunogen

Conjugate

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

Excitation/Emission Max

499/520 nm View spectra spectra

Form

Liquid

Concentration

0.32 mg/mL

Purification

Size-exclusion chromatography

Storage buffer

TBS with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913055

Product Specific Information

This antibody recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

Target Information

CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD61 non-covalently associates with CD41.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alphaIIb protein; antigen CD61; glycoprotein IIIa precursor; GPalpha IIb; Integrin alpha-2b; integrin beta 3; integrin beta chain, beta 3; integrin beta-3; integrin beta-3 subunit; integrin homolog; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb (GPIIb); platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet membrane glycoprotein IIIa; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93; unnamed protein product

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Gene Aliases: BDPLT16; BDPLT2; BDPLT24; CD41; CD41B; CD61; FMAIT1; FMAIT2; GP2B; GP3A; GPIIb; GPIIIa; GT; GT1; GT2; GTA; HPA3; PPP1R93

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UniProt ID: (Human) P08514, (Human) P05106

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Entrez Gene ID: (Human) 3674, (Human) 3690

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Function(s)
obsolete cell adhesion receptor activity protein binding signaling receptor activity identical protein binding extracellular matrix binding binding, bridging fibrinogen binding fibronectin binding protease binding protein disulfide isomerase activity protein kinase C binding platelet-derived growth factor receptor binding integrin binding coreceptor activity fibroblast growth factor binding enzyme binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding
Process(es)
angiogenesis positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion cell-cell adhesion positive regulation of endothelial cell proliferation embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading tube development wound healing, spreading of epidermal cells response to platelet-derived growth factor apolipoprotein A-I-mediated signaling pathway wound healing apoptotic cell clearance regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell mesodermal cell differentiation positive regulation of smooth muscle cell proliferation negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of transport regulation of multicellular organismal process regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration
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