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Invitrogen

Phospho-INSR (Tyr1361) Polyclonal Antibody

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Phospho-INSR (Tyr1361) Polyclonal Antibody

Product Details

PA5-104754

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human INSR(Accession P06213), corresponding to amino acid residues around phosphorylated Tyr1361.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816227

Product Specific Information

Antibody detects endogenous levels of IR only when phosphorylated at Tyrosine 1361.

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD 220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; insulin receptor precursor; insulin receptor preproprotein; IR; IR 1; IR beta; IR-1; IR1; type II receptor tyrosine kinase; unnamed protein product

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Gene Aliases: 4932439J01Rik; CD220; D630014A15Rik; HHF5; IR; IR-A; IR-B

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UniProt ID: (Human) P06213, (Mouse) P15208

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Entrez Gene ID: (Human) 3643, (Rat) 24954, (Mouse) 16337

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Function(s)
beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding structural molecule activity protein binding ATP binding GTP binding protein domain specific binding protein kinase activator activity insulin-like growth factor I binding insulin-like growth factor II binding cargo receptor activity identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding PTB domain binding protein kinase binding protein phosphatase binding lipoic acid binding 3-phosphoinositide-dependent protein kinase binding
Process(es)
response to hypoxia liver development negative regulation of protein phosphorylation positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of gluconeogenesis regulation of transcription, DNA-templated protein phosphorylation receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development response to hormone response to glucose organ morphogenesis response to manganese ion regulation of hydrogen peroxide metabolic process regulation of gene expression positive regulation of glycoprotein biosynthetic process negative regulation of gene expression regulation of glucose metabolic process response to activity peptidyl-tyrosine phosphorylation cerebellum development hippocampus development male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development response to nutrient levels response to food response to estradiol negative regulation of transporter activity response to insulin cellular response to insulin stimulus response to vitamin D response to testosterone cellular response to zinc ion starvation response to tumor necrosis factor peptidyl-tyrosine autophosphorylation positive regulation of phosphorylation glucose homeostasis response to starvation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process fat cell differentiation response to ethanol negative regulation of glycogen biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import viral entry into host cell protein autophosphorylation animal organ development positive regulation of developmental growth system development positive regulation of cellular component organization regulation of multicellular organismal process response to glucocorticoid positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus dendritic spine maintenance beta-amyloid clearance liver regeneration response to vanadate(3-) response to resveratrol embryonic liver development neuron projection maintenance regulation of female gonad development negative regulation of feeding behavior learning memory transport across blood-brain barrier
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