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Invitrogen
Human NIFK (aa 181-261) Control Fragment Recombinant Protein
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Product Details
RP-104083
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
IDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVSGTLDTPEKTVDSQGPTPVCTPTFLERRKSQVAELNDDDKDDEI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (48%), Rat (48%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83283. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
NIFK, also known as nucleolar protein interacting with the forkhead homolog protein, is a gene associated with several cancer types and is considered a potential prognostic biomarker. This gene functions within the nucleolus and plays a critical role in cellular proliferation, metastasis, and invasiveness, particularly noted in hepatocellular carcinoma (HCC) and colorectal cancer. NIFK expression is regulated via several pathways, including the MYC proto-oncogene pathway, and its silencing can lead to decreased fatty acid synthesis in colorectal cancer cells. Furthermore, it's involved in the regulation of innate immunity through pathways such as NF-kB in specific cancer cells. Due to its involvement in cancer progression, NIFK is being explored as a therapeutic target and holds promise for advancing precision medicine strategies across various cancer treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hNIFK; Ki67ip; MKI67 (FHA domain) interacting nucleolar phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI-67
Gene Aliases: MKI67IP; NIFK; NOPP34
UniProt ID: (Human) Q9BYG3
Entrez Gene ID: (Human) 84365
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