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Invitrogen
NIFK Polyclonal Antibody
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Product Details
PA5-83283
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NIFK. Recombinant protein control fragment (Product #RP-104083).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IDYDFPSLIL QKTESISKTN RQTSTKGQVL RKKKKKVSGT LDTPEKTVDS QGPTPVCTPT FLERRKSQVA ELNDDDKDDE I
Highest antigen sequence indentity to the following orthologs: Mouse - 48%, Rat - 43%.
Target Information
NIFK, also known as nucleolar protein interacting with the forkhead homolog protein, is a gene associated with several cancer types and is considered a potential prognostic biomarker. This gene functions within the nucleolus and plays a critical role in cellular proliferation, metastasis, and invasiveness, particularly noted in hepatocellular carcinoma (HCC) and colorectal cancer. NIFK expression is regulated via several pathways, including the MYC proto-oncogene pathway, and its silencing can lead to decreased fatty acid synthesis in colorectal cancer cells. Furthermore, it's involved in the regulation of innate immunity through pathways such as NF-kB in specific cancer cells. Due to its involvement in cancer progression, NIFK is being explored as a therapeutic target and holds promise for advancing precision medicine strategies across various cancer treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hNIFK; Ki67ip; MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI-67; unnamed protein product
Gene Aliases: MKI67IP; NIFK; NOPP34
UniProt ID: (Human) Q9BYG3
Entrez Gene ID: (Human) 84365
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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