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Allergen Encyclopedia
Table of Contents

Whole Allergen

w207 Lupin

w207 Lupin Scientific Information

Type:

Whole Allergen

Display Name:

Lupin

Allergen code:

w207

Family:

Fabaceae (Leguminosae)

Latin Name:

Lupinus spp.

Other Names:

Lupin, Lupine

Route of Exposure

Other topics

The seed may be cooked and eaten. The seed is also ground into flour and may be mixed with cereal flours for making bread. Some varieties have bitter seeds that contain toxic alkaloids and require leaching before they are eaten, but varieties without alkaloids have been developed. The roasted seeds can be used as a snack in much the same way as peanuts. Edible oil is obtained from the seed. The roasted seed is used as a coffee substitute.

Food allergy, asthma and occupational allergy to Lupin flour. (1, 2) See Lupin f335 for information on allergy to Lupin seed.

Clinical Relevance

IgE mediated reactions

Anecdotal evidence suggests that asthma, allergic rhinitis and allergic conjunctivitis are common following exposure to pollen from Lupin; however, few specific studies have been reported to date. (3)

Molecular Aspects

No allergens from the pollen of this plant have yet been characterised. A number of allergens have been characterised in the seed. However, it has been demonstrated that stress on Lupin could activate a class-III chitinase, IF3. The protein was detected in the seed, leaves and roots. A thaumatin-like protein was also detected. The authors state that ”the ubiquitous presence of this enzyme in healthy, non-stressed tissues of L. albus cannot be explained.” The pollen was not evaluated for the presence of this allergen. (4). A 2S albumin has been isolated from the seed but not from the pollen as yet.(5)

Cross-reactivity

An extensive cross-reactivity among the different individual species of the genus could be expected, as well as to a certain degree among members of the family Fabaceae. (6)

Compiled By

Last reviewed:April 2022

References
  1. Crespo JF, Rodríguez J, Vives R, James JM, Reaño M, Daroca P, et al. Occupational IgE-mediated allergy after exposure to lupine seed flour. The Journal of allergy and clinical immunology. 2001;108(2):295-7.
  2. Parisot L, Aparicio C, Moneret-Vautrin DA, Guerin L. Allergy to lupine flour. Allergy. 2001;56(9):918-9.
  3. Lavaud F, Jonvel AC, Fontaine JF, Sabouraud D, Lebargy F. Les pollinoses de proximité ne sont-elles que des cas cliniques ? Revue de la littérature à propos de cinq observations / Pollinosis of proximity: Review of the literature and report of five cases. Revue francaise d allergologie 2007;41(2):51-6.
  4. Regalado AP, Ricardo CP. Study of the intercellular fluid of healthy Lupinus albus organs. Presence of a chitinase and a thaumatin-like protein. Plant physiology. 1996;110(1):227-32.
  5. Egorov TA, Odintsova TI, Musolyamov A, Fido R, Tatham AS, Shewry PR. Disulphide structure of a sunflower seed albumin: conserved and variant disulphide bonds in the cereal prolamin superfamily. FEBS letters. 1996;396(2-3):285-8.
  6. L. Y. Botanical relations and immunological cross-reactions in pollen allergy. 2nd ed. Pharmacia Diagnostics AB. Uppsala. Sweden. Pharmacia Diagnostics AB Uppsala Sweden. 1982.