Laboratory Testing for Autoimmune Thyroid Diseases
Bringing Clarity to the Underlying Cause

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The inflammation of the thyroid gland (thyroiditis) can lead to its dysfunction, affecting the whole body and leading to a loss in the quality of life.1 Autoimmune thyroid diseases (AITD), such as Hashimoto’s thyroiditis and Graves’ disease, affect up to 5 percent of the population in Western countries, and are one of the main etiologies of hyper- and hypothyroidism.1 Enabling clinicians to differentiate these diseases from non-autoimmune thyroid dysfunction and to make well-informed treatment decisions lead to better patient care.1,2

 

The measurement of autoantibodies directed against thyroid proteins is a pivotal part of the diagnostic algorithm of both Hashimoto’s thyroiditis and Graves’ disease.1,2

The most relevant thyroid autoantibodies are:

  • Anti-TSH-R: A specific serological marker for the differential identification of Graves’s diseases from other causes of hyperthyroidism and thyrotoxicosis.3
  • Anti-TPO: A serological marker for the diagnosis of Hashimoto’s thyroiditis but also detectable in up to 80 percent of Graves’ disease patients. 4
  • Anti-TG: Often detected together with anti-TPO, but approximately 6 percent of patients with Hashimoto’s thyroiditis are single positive for anti-TG.5

 


 

Why choose Thermo Fisher Scientific as your partner for autoimmune thyroid disease diagnosis?

 

Helping detect AITD correctly, the first time

In diseases such as AITD, where patients can often present with vague symptoms, specificity is key. With EliA™ anti-TSH-R, EliA™ anti-TPO and EliA™ anti-TG tests, we offer a fully automated and specific autoantibody test panel to support the diagnosis of AITD. In a comparison with other automated thyroid tests, EliA™ thyroid tests had the highest specificity rates (EliA anti-TSH-R test: 97.7%; manufacturer 1: 92.0%, manufacturer 2: 94.0%; EliA anti-TPO test: 96.0%, manufacturer 1: 94.0%, manufacturer 2: 91.0%; EliA anti-TG: 94%, manufacturer 1: 90.5%, manufacturer 2: 94.0%).6

 

Manufactured to the highest standards to ensure clinical relevance

The antigens for EliA anti-TSH-R and EliA anti-TPO tests are produced with high purity and reproducibility in a eukaryotic expression system. This ensures a high lot-to-lot consistency with maximum accuracy and precision within and between lots.

 

Optimized for lean working

EliA thyroid tests enable you to perform all three relevant antibody tests from one sample in one run and on the same fully automated Phadia™ Laboratory Systems. This means that you and your clinical customers can apply the same thyroid positive control for all EliA thyroid tests and share common system reagents, saving time and reducing costs.

 

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References
  1. Rema J, Ramos JP,Dias C. Autoimmune thyroid diseases in The General Practice Guide to Autoimmune Diseases. Pabst Science Publishers, Lengerich 2012:267-271.
  2. Franco JS, Amaya-Amaya J, Anaya JM. THYROID DISEASE AND AUTOIMMUNE DISEASES. In AUTOIMMUNITY From Bench to Bedside. editors: Anaya JM, Sheonfeld Y, Rojas-Villarraga A, Levy RA, Cervera R. Bogota, Columbia: El Rosario University Press; 2013:537-561.
  3. Menconi F, Marcocci C, Marino M. Diagnosis and classification of Graves' disease. Autoimmun Rev. 2014;13(4-5):398-402.
  4. Saravanan P, Dayan CM. Thyroid autoantibodies. Endocrinol Metab Clin North Am. 2001;30(2):315-337, viii.
  5. Tozzoli R, Villalta D, Kodermaz G, Bagnasco M, Tonutti E, Bizzaro N. Autoantibody profiling of patients with autoimmune thyroid disease using a new multiplexed immunoassay method. Clin Chem Lab Med. 2006;44(7):837-342.
  6. Scientfic TF. Internal study. Data on file. Anti-TSH-R: serum samples from 100 Graves’ disease patients and 300 disease controls. Anti-TPO and anti-TG: serum samples from 100 Graves’ disease and 100 Hashimoto’s thyroiditis patients and 200 disease controls.