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According to international classification criteria, identification of APS requires the presence of vascular thrombosis and/or pregnancy morbidity, along with at least one of the following antiphospholipid antibody tests, which are often performed in parallel: 1
According to the 2013 ACR/EULAR classification criteria for Systemic Sclerosis, patients with a total score of ≥9 are classified as having definite SSc.5
According to the 2017 EULAR/ACR classification criteria for adult and juvenile IdiopathicInflammatory Myopathies (IMM) and their major subgroups, includingpolymyositis/dermatomyositis, patients with probability above 55 percent, when no better explanation for the symptoms or signs exists, are classified as having IIM.6
There is overlapping diagnostic criteria for MCTDs. A comparison study determined that MCTD was best identified with the Alarcón-Segovia criteria and the Kahn criteria.7
The Alarcón-Segovia diagnostic criteria:
The Kahn diagnostic criteria:
Serological testing can help differentiate this disease and provide an accurate, expedited diagnosis. It may help to consider testing when there is presentation of gastrointestinal (GI) symptoms or a new diagnosis for a condition that increases the risk for having CD.8
International classification criteria advocates for serologic testing to help aid in the diagnosis of celiac disease. The European Society for Pediatric Gastroenterology, Hepatology and Nutrition has published guidelines for the diagnosis of celiac disease for children or adolescents with otherwise unexplained symptoms and signs suggestive of CD.9 It states that children should be tested for:
In the UK, the National Institute for Health and Care Excellence encourages young people and adults to be tested for:10
The American College of Gastroenterology recommends that adults in whom celiac disease is suspected by testing according to the following algorithms.3
Adapted from Husby, et al 2012, Werkstetter et al., 2017, and World Health Organization, 2015. Please be aware that additional analytical parameters can be necessary.
Numerous international guidelines recommend RF IgM and anti-CCP as first-line tests to aid in the diagnosis of rheumatoid arthritis. CCP antibodies appear in the early stages of rheumatoid disease.19,20
International guidelines classification criteria also recommend laboratory testing for:
Many tests measure rheumatoid factor (RF) using nephelometry or turbidometry. However, using an RA panel that can distinguish between the different RF isotypes—RF IgA and RF IgM in particular—can give you important additional diagnostic guidance.21-23
International guidelines recommend positive serology for ANCAs. These diagnostic tools can help you identify the disease and start your patients on the road to treatment for granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA).24
The revised 2017 international consensus on testing of ANCAs in GPA and MPA proposes that high-quality immunoassays for MPO and PR3 antibodies should be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the need for indirect immunofluorescence (IIF).24