TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
capacitative calcium channel TRPC7; hTRP7; KNP3; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7; putative capacitative calcium channel; Short transient receptor potential channel 7; transient receptor potential cation channel subfamily C member 7; transient receptor potential cation channel, subfamily C, member 7; Transient receptor protein 7; TRP-7; TrpC7; TRPM2