Specific protein assays

Your partner in targeted protein analysis


What are specific protein assays?

Specific protein assays determine the amount or concentration of a specific protein or an array of different proteins in a sample.

Different assays in this group may aid in the characterization of a number of disorders. Individual assays in this group may aid in the characterization of:

  • Chronic heart diseases
  • Autoimmune disorders
  • Infections
  • Hemolytic diseases (anemias)
  • Metabolic disorders and other diseases
Optilite® Analyser provides automated specific protein assays with enhanced efficiency and optimized workflow

Range of assays

The following assays are included in the specific protein assay range

Cardiac assays

  • Apolipoprotein A1 and B
  • High sensitive C-reactive protein
  • Lipoprotein (a)

Inflammation assays

  • A1 Acid Glycoprotein
  • A1 Antitrypsin
  • ASO
  • CRP
  • Rheumatoid factor

Other assays

  • Caeruloplasmin
  • Haptoglobin
  • Prealbumin
  • Tetanus Toxoid**
  • Total Protein
  • Transferrin


**Automated assay unique to Binding Site.
Abbreviation: ASO - Antistreptolysin O; CRP – C-reactive protein 
  • Apolipoprotein A1 & B
    • Measurement of Apo A1 and B levels can aid in the assessment of cardiovascular disease and lipoprotein metabolism disorders
    • Apo A1 can aid in the assessment of risk of atherosclerotic cardiovascular disease
  • Lipoprotein (a)
    • Assessment of lipid disorders
    • Assessment of risk of atherosclerotic cardiovascular disease
    • Measurement of Lp(a), alongside LDL-cholesterol, HDL-cholesterol, apolipoprotein A-1 and apolipoprotein B, is a valuable tool in evaluation of CHD
  • High sensitive C-reactive protein (hs CRP)
    • hsCRP can aid in identification of inflammation

With regard to lipoprotein (a), the European Atherosclerosis Society recommends measurements in molar (nmol/L) scale rather than mass scale (g/L).1 As such, the Binding Site lipoprotein (a) assay measures lipoprotein (a) in nmol/L.

  • Anti-Streptolysin O (ASO)- Can be used to establish the degree of infection past or present, by β-haemolytic streptococci
  • Rheumatoid Factor (RF)- A marker that may aid in the characterisation of rheumatoid arthritis 
  • ɑ1 Acid Glycoprotein & C Reactive Protein are acute phase reactants raised in acute & chronic inflammatory conditions 
  • ɑ1 Antitrypsin deficiency may lead to conditions like pulmonary emphysema
  • High sensitive C-reactive protein (hs CRP) can aid in identification of inflammation
  • Anti-tetanus toxoid - Quantitatively measures anti-tetanus antibodies in EDTA plasma or serum
  • Haptoglobin - A diagnostic marker for hemolytic diseases such as anemia, liver disease and inflammatory conditions
  • Caeruloplasmin -  A diagnostic marker for copper metabolism disorders, such as Menkes or Wilson’s disease
  • Prealbumin - Helps in determination of nutritional status 
  • Total protein - Measurement of total proteins in blood can aid in detection of disorders such as:
    • Hypoproteinemia (which may be due to defective protein synthesized in the liver, protein loss due to impaired kidney function, intestinal malabsorption or nutritional deficiency) 
    • Hyperproteinemia (which may be due to chronic inflammatory disorders, liver cirrhosis and dehydration) 
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The Optilite Analyser utilizes proven turbidimetric technology, which is known to be fast, robust and versatile, becoming the main technology for protein diagnostics worldwide
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1. Nordestgaard, B.G., Chapman, M.J., Ginsberg, H.N., The European Atherosclerosis Society Consensus Panel. (2012). Lipoprotein(a): EAS recommendations for screencing, desirable levels and management