Episode 044

Unraveling Complex Allergy Case Studies with the Power of Allergen Components

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Episode summary

Did you know that a dog allergy could be linked to unexplained infertility? This episode delves into fascinating allergy case studies and how component-resolved diagnostics can help uncover hidden connections. From wheat-dependent exercise-induced anaphylaxis in children to severe sesame reactions despite negative clinical history, learn what these interesting cases can teach us about the impact of allergen component sensitization and how innovative testing using components can broaden our understanding. This episode also explores the latest insights into wheat and sesame allergen components as well as how these tools can enhance your clinical decision-making, improve diagnostic accuracy, and optimize allergy management strategies.

Episode resources

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Lab Ordering Guide

Looking for allergy diagnostic codes from the labs you already use?

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Wheat allergy component resolved diagnostics

Ses i 1 (sesame) allergen component

Stinging insect hypersensitivity: A practice parameter update 2016

Episode transcript

Time stamps

0:00 - Introduction

1:34 - Case study: Unexplained infertility and Can f 5 sensitization

5:33 - Case study: Wheat-dependent exercise-induced anaphylaxis

12:50 - Discussion on wheat allergen components

15:33 - Case study: Sesame allergy and oral food challenge

21:34 - Case study: Stinging insect allergy in a 2-year-old

26:23 - Stinging insect allergen components analysis

29:44 - Conclusion

References used in this episode

Didziokaite G, Kuznecovaite A, Biliute G, Kvedariene V. Case report: Human seminal plasma allergy diagnosis for a woman with unexplained infertility. Front Med (Lausanne). 2024 Aug 29;11:1403477.
Nowak-Wegrzyn, AH. Symposium at the annual meeting of the American Academy of Allergy, Asthma, and Immunology (AAAAI).
Dramburg S. et al. EAACI Molecular Allergology User's Guide 2.0. Pediatr Allergy Immunol. 2023 Mar;34 Suppl 28:e13854
Falcetano, G. (Host). (2025). Confirmed Peanut Allergy, Sesame Sensitized [Audio podcast episode]. In ImmunoCAST Podcast. Thermo Fisher Scientific. https://www.thermofisher.com/phadia/us/en/resources/immunocast.html
Falcetano, G. (Host). (2025). Case Study: Stung Toddler [Audio podcast episode]. In ImmunoCAST Podcast. Thermo Fisher Scientific. https://www.thermofisher.com/phadia/us/en/resources/immunocast.html
Golden DB. et al. Stinging insect hypersensitivity: A practice parameter update 2016. Ann Allergy Asthma Immunol. 2017 Jan;118(1):28-54.
Spillner E, Blank S, Jakob T. Hymenoptera allergens: from venom to "venome". Front Immunol. 2014 Feb 28;5:77.